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Table 2 Modified International Cartilage Repair Society scoring system for cartilage repair

From: Radial shockwave treatment promotes human mesenchymal stem cell self-renewal and enhances cartilage healing

Stain Histologic parametera Scoreb
Safranin O/Fast Green Surface/superficial architecture Cartilage defect
Adjacent
Inflammatory cell infiltrate Cartilage defect
Adjacent
Repair–host integration Cartilage defect
Basal neocartilage–bone integration Cartilage defect
Surface/superficial assessment Cartilage defect
Adjacent
Mid/deep zone assessment Cartilage defect
Adjacent
Overall assessment Cartilage defect
Adjacent
Matrix staining (metachromasia) Cartilage defect
Adjacent
Calcification/ossification Cartilage defect
Adjacent
Subchondral bone vascularization Bone subchondral
Surrounding
Presence of bone void (with or without fibrovascular tissue and without secretory lining), yes/no Bone subchondral
Immunohistochemistry C2: type II collagen Cartilage defect
Adjacent
  1. aDefect is defined as the area of the original cartilage defect adjacent to the surface of the cartilage with 2 mm surrounding the defect and surrounding the sides and bottom of the defect
  2. bScores assigned on a 0–100 scale, 100 being normal