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Table 2 Modified International Cartilage Repair Society scoring system for cartilage repair

From: Radial shockwave treatment promotes human mesenchymal stem cell self-renewal and enhances cartilage healing

Stain

Histologic parametera

Scoreb

Safranin O/Fast Green

Surface/superficial architecture

Cartilage defect

Adjacent

Inflammatory cell infiltrate

Cartilage defect

Adjacent

Repair–host integration

Cartilage defect

Basal neocartilage–bone integration

Cartilage defect

Surface/superficial assessment

Cartilage defect

Adjacent

Mid/deep zone assessment

Cartilage defect

Adjacent

Overall assessment

Cartilage defect

Adjacent

Matrix staining (metachromasia)

Cartilage defect

Adjacent

Calcification/ossification

Cartilage defect

Adjacent

Subchondral bone vascularization

Bone subchondral

Surrounding

Presence of bone void (with or without fibrovascular tissue and without secretory lining), yes/no

Bone subchondral

Immunohistochemistry

C2: type II collagen

Cartilage defect

Adjacent

  1. aDefect is defined as the area of the original cartilage defect adjacent to the surface of the cartilage with 2 mm surrounding the defect and surrounding the sides and bottom of the defect
  2. bScores assigned on a 0–100 scale, 100 being normal