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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Engineering a multicellular vascular niche to model hematopoietic cell trafficking

Fig. 4

Microenvironment cues do not change CD34+ HSPC localization. a CD34+ HSPCs perfused through unmodified, HS5-, and HS27a-modified vessels adhere to the endothelium (not stained) and transmigrate into the matrix. Scale bars = 100 μm. b CD34+ cells from a are shown alone with outlines of vessel walls (yellow dotted lines). c Quantification of CD34+ HSPC adhesion and migration shows the percentage of cells adhered and migrated within vessels. d Scanning electron microscopic image of an hematopoietic stem cell (HSC) adhered and transmigrating through the endothelium in a vessel construct. EC endothelial cell

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