Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation

Fig. 3

LRRC15 knockdown inhibits the osteogenic differentiation of MSCs in vivo. A LRRC15 knockdown impaired MSC-mediated bone-like tissue formation in vivo, measured by H&E staining of histological sections from implanted MSC-scaffold hybrids. Scale bar represents 50 μm. Quantitative measurements of bone-like tissues showed the area of bone formation was significantly lessened in LRRC15 knockdown cells compared with NC cells. B Masson’s trichrome staining of histological sections from implanted MSC-scaffold hybrids. Scale bar represents 50 μm. C Immunohistochemistry staining of OCN. Scale bar represents 50 μm. All data shown as mean ± SD, n = 3. **P < 0.01. NC negative control cells, H&E hematoxylin and eosin, LRRC15sh LRRC15 knockdown cells, LRRC15 fifteen-leucine-rich repeat containing membrane protein, OCN osteocalcin

Back to article page