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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells

Fig. 5

Gas5 is regulated by the Dicer-miR291a–cMyc pathway in ESCs. a The expression of Gas5 in Dicer knockdown (KD) mouse embryonic stem cells (mESCs). b The expression of Gas5 in miR-291a KD mESCs c Overexpression of miR-291a restores the expression of Gas5 in Dicer knockdown mESCs. d The expression of Gas5 in cMyc KD mESCs. e Enforced expression of cMyc rescues the expression of Gas5 in Dicer and miR-291a KD mESCs. *P < 0.05, **P < 0.01, t test, n = 3. Error bars represent SEM of the indicated experiment replicates. lncRNA long noncoding RNA, NC normal control

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