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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells

Fig. 6

Gas5 induces iPSC reprogramming efficiency. a Endogenous expression of Gas5 in mouse embryonic fibroblasts (MEFs) and reprogrammed induced pluripotent stem cells (iPSCs). b,c Morphology and quantitative analysis of Oct4-GFP+ cells during Gas5 knockdown (KD) and control (NC) MEF reprogramming. d Alkaline phosphatase staining results in Gas5 KD-MEF-formed iPSC clones and control MEF-formed iPSC clones. e Endogenous expression of pluripotent markers Oct4, Sox2, and Nanog during Gas5 KD MEF- and control MEF-mediated reprogramming. **P < 0.01, t test, n = 3. Error bars represent SEM of the indicated experiment replicates

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