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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis

Fig. 3

a Angiogenic cytokine gene expression of iPSC-ECs cultured on tissue culture plastic (TCP) and PG73 (16 ml/h scaffolds) in normoxia vs hypoxia. Values presented as fold change normalized to normoxia. *p < 0.05, **p < 0.01. n = 5 samples/group. b In-vivo engraftment curves measured through IVIS bioluminescence measurement of iPSC-ECs and iPSC-EC-seeded PG73 scaffolds over 5 days. ***p < 0.001, *p < 0.05. n = 5 samples (animals)/group. c Area under the curve quantification of engraftment bioluminescence curves. *p < 0.05. n = 5 samples (animals)/group. d Representative bioluminescence photographs of animals implanted with experimental groups over 5 days. EGF epidermal growth factor, PlGF placental growth factor, VEGF vascular endothelial growth factor, PG73 polycaprolactone/gelatin (70:30 ratio), iPSC-EC induced pluripotent stem cell-derived endothelial cell, AUC area under the curve

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