Fig. 4
From: MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells
Methylation analysis of SIRT1 CpG islands. a One CpG island in SIRT1 promoter region. b, c, d Bisulfite promoter analysis for SIRT1 methylation after viral MeCP2 overexpression (black presents methylation location). Data reported as mean ± SD, n = 3. *P < 0.05 vs GFP. CpG cytosine-guanine dinucleotide sequences, TSS transcriptional start site, GFP green fluorescent protein, MeCP2 methyl-CpG-binding protein 2, SIRT1 sirtuin 1