Fig. 5
From: MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells
Mechanism of MeCP2-inhibited SIRT1 transcription. a ChIP against MeCP2 shows more MeCP2 enrichment on SIRT1 promoter in MeCP2-overexpressed EPCs. b ChIP against H3K9me2 shows more H3K9me2 enrichment on SIRT1 promoter in MeCP2-overexpressed EPCs than control. c Proposed mechanism of senescent EPC dysfunction. n = 3. *P < 0.05 vs GFP. GFP green fluorescent protein, MeCP2 methyl-CpG-binding protein 2, H3K9me2 Histone 3 Lysine 9 dimethylation, SIRT1 sirtuin 1, CpG cytosine-guanine dinucleotide sequences