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Table 1 Mitochondrial transfer from different kinds of stem cells

From: Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury

Donor cells

Recipient cells

Defects

Methodologies

Effects

References

MSCs

A549 ρ° cells

Lack of functional mitochondria

In vitro: coculture

Rescue aerobic respiration

[25]

IPSCs

MSCs

Airway epithelial cells

CS induced

In vitro: coculture

In vivo: intravenous injection

Preservation of ATP levels

[48]

MSCs

T cells

Systemic lupus erythematosus

In vitro: coculture

Regulation of autophagy

[50]

MSCs

CECs

Rotenone-induced oxidative stress

In vitro: coculture

Mitochondrial function rescued

[68]

IPSCs

MSCs

Myocardial cells

Anthracycline-induced damage

In vitro: coculture

Protection of damage

[85]

BMSCs

Alveolar epithelial cells

ALI

In vivo: airway instilled

Mitochondrial function rescued

[38]

BMSCs

Alveolar macrophages

ARDS

In vitro: coculture

Improvement of phagocytic capacity

[40]

BMSCs

H9c2 cells

Ischemia–reperfusion

In vitro: coculture

Reduction of apoptosis

[87]

BMSCs

Nucleus pulposus cells

Degenerative disc diseases

In vitro: coculture

Reduction of apoptosis

[88]

MSCs

Neurons

Ischemia–reperfusion

In vitro: coculture

In vivo: intravenous injection

Reduction of brain lesion volume

[86]

MSCs

HUVECs

Ischemia–reperfusion

In vitro: coculture

Reduction of apoptosis and rescue of aerobic respiration

 

BMSCs

Myocardial cells

None

In vitro: coculture

Reprogramming to the progenitor state

[22]

Endothelial progenitor cells

ECs

Adriamycin induced

In vivo: tail intravenous injection

Reduction of inflammation and apoptosis

[89]

MSCs

ECs

Asthma

In vitro: coculture

In vivo: intravenous injection

Mitochondrial respiratory function rescued

 
  1. ALI acute lung injury, ARDS acute respiratory distress syndrome, ATP adenosine triphosphate, BMSC bone marrow mesenchymal stem cell, CS cigarette smoke, EC epithelial cell, HUVEC human umbilical vein endothelial cell, IPSC induced pluripotent stem cell, MSC stem cell including mesenchymal stem cell, CECS cornneal epithelial cells