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Table 1 Mitochondrial transfer from different kinds of stem cells

From: Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury

Donor cells Recipient cells Defects Methodologies Effects References
MSCs A549 ρ° cells Lack of functional mitochondria In vitro: coculture Rescue aerobic respiration [25]
IPSCs
MSCs
Airway epithelial cells CS induced In vitro: coculture
In vivo: intravenous injection
Preservation of ATP levels [48]
MSCs T cells Systemic lupus erythematosus In vitro: coculture Regulation of autophagy [50]
MSCs CECs Rotenone-induced oxidative stress In vitro: coculture Mitochondrial function rescued [68]
IPSCs
MSCs
Myocardial cells Anthracycline-induced damage In vitro: coculture Protection of damage [85]
BMSCs Alveolar epithelial cells ALI In vivo: airway instilled Mitochondrial function rescued [38]
BMSCs Alveolar macrophages ARDS In vitro: coculture Improvement of phagocytic capacity [40]
BMSCs H9c2 cells Ischemia–reperfusion In vitro: coculture Reduction of apoptosis [87]
BMSCs Nucleus pulposus cells Degenerative disc diseases In vitro: coculture Reduction of apoptosis [88]
MSCs Neurons Ischemia–reperfusion In vitro: coculture
In vivo: intravenous injection
Reduction of brain lesion volume [86]
MSCs HUVECs Ischemia–reperfusion In vitro: coculture Reduction of apoptosis and rescue of aerobic respiration  
BMSCs Myocardial cells None In vitro: coculture Reprogramming to the progenitor state [22]
Endothelial progenitor cells ECs Adriamycin induced In vivo: tail intravenous injection Reduction of inflammation and apoptosis [89]
MSCs ECs Asthma In vitro: coculture
In vivo: intravenous injection
Mitochondrial respiratory function rescued  
  1. ALI acute lung injury, ARDS acute respiratory distress syndrome, ATP adenosine triphosphate, BMSC bone marrow mesenchymal stem cell, CS cigarette smoke, EC epithelial cell, HUVEC human umbilical vein endothelial cell, IPSC induced pluripotent stem cell, MSC stem cell including mesenchymal stem cell, CECS cornneal epithelial cells