Table 1 Properties and markers used to identify fibrocytes
Property | Expression |
|---|---|
Functions | |
 Cytokine production | ++ |
 Immune cell trafficking | ++ |
 ECM production | ++ |
 α-SMA production | + |
 Lipid metabolism | + |
 Antigen presentation | ++ |
 Angiogenesis | + |
 MMP production | + |
 Chitinase production | + |
 Growth factors (TGF-β1, MCP-1) | +/++ |
Monocyte markers | |
 CD11a, CD11b, CD11c, CD13, CD32, CD64 | +/++ |
 CD14 | +/− |
 CD16 | – |
Stem cell/progenitor markers | |
 CD34 | ++ |
 CD105 | ++ |
Dendritic cell markers | |
 CD1a, Cd10, CD83 | – |
B cell markers | |
 CD19 | – |
T cell markers | |
 CD3, CD4, CD8, CD25, CD56 | – |
Macrophages markers | |
 CD45RO, 25F9, S100A8/A9 | + |
 PM-2 K | – |
Integrins | |
 CD18, CD29, CD49b, CD49e, CD61 | ++ |
 CD49a | + |
 CD49c, CD49d, CD49f, CD103, α4β7 | – |
Cell surface enzymes | |
 CD10, CD172a | + |
 proly14-hydroxylase | + |
 FAP | + |
Scavenging receptors and molecules involved in host defense | |
 CD68, CD163, CD206, CD209, CD35, CD36 | +/− |
Chemokine receptors | |
 CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CCR9, CXCR1, CXCR4, CX3CR1, CXCR3 | +/++ |
Antigen presentation | |
 CD40, CD54, CD80, CD86, MHC class I and II | ++/+ |
Extracellular matrix proteins | |
 Collagen I, III and IV, vimentin, tenascin | + |
 Fibronectin, α-SMA | +/− |
 Collagen V | ++ |
 MMP-9 | ++ |
Glycosaminoglycans | |
 Perlecan, versican, hyaluronan | ++/+ |
 Decorin, biglycan | + |
Adhesion and motility markers | |
 CD43, CD164, galectin 3, LSP1 | +/++ |
 CD29, CD44, CD81, ICAM1, CD81 | + |
Miscellaneous | |
 Semaphorin 7A | + |
 CD115 | – |
 CD90 | +/− |
 CD105 | + |
 CD70 | – |
 vWF | – |