Allogeneic transplantation of mobilized dental pulp stem cells with the mismatched dog leukocyte antigen type is safe and efficacious for total pulp regeneration

Iohara, Koichiro; Utsunomiya, Shinji; Kohara, Sakae; Nakashima, Misako

doi:10.1186/s13287-018-0855-8

Stem Cell Research & Therapy

Table 6 Safety evaluation by hematology and blood chemistry at 4 and 12 weeks after the first and the second allogeneic transplantation

From: Allogeneic transplantation of mobilized dental pulp stem cells with the mismatched dog leukocyte antigen type is safe and efficacious for total pulp regeneration

Individual number	RBC (10⁶/μl)				WBC (10³/μl)				Platelet count (10³/μl)				Hematocrit (%)
	First transplant		Second transplant		First transplant		Second transplant		First transplant		Second transplant		First transplant		Second transplant
	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks
Hematology
13MW 302	6.33	6.79	6.65	6.73	12.78	12.94	11.91	13.65	286	316	281	259	42.5	46.1	44.2	44.4
13FW 191	6.62	6.58	7	7.32	7.03	10.49	9.08	10.83	388	538	434	400	43.4	45.8	47.6	48.1
13FW 283	6.22	6.4	6.41	7	12.36	13.4	16.78	14.14	400	439	360	334	43.8	46.6	46.5	48.4
13FW 956	7.03	6.8	6.84	7.51	8.9	12.99	10.9	10.77	362	342	323	321	46.6	45.9	46	49.4
13MW 1029	7.3	6.87	7.31	7.57	9.19	12.31	11.82	14.42	300	249	256	274	48.9	46	47.8	50.6
13FW 300	6.79	6.75	7.29	6.9	8.79	8.08	7.86	8.52	387	313	274	317	44.4	45.4	47.3	44.4
13FW 299	7.71	7	7.39	8.34	11.35	9.68	10.92	9.27	306	259	277	221	52.4	47.8	50.6	55.9
13FW 1031	6.56	7.16	8.01	6.9	11.74	15.75	15.64	12.87	327	300	364	345	44.5	50	55.3	46.9
13FW 926	7.82	8.26	8.42	7.49	10.18	9.6	11.05	11.32	369	338	347	413	56.9	58.3	58.7	53.3
13MW 1122	7.07	6.94	6.91	7.11	8.37	8.8	7.83	8.41	285	278	265	271	49.5	48.8	47.8	49.2
	AST (IU/L)				ALT (IU/L)				Albumin (g/dl)				Globulin (g/dl)				Total cholesterol (mg/dl)				Glucose (mg/dl)
	First transplant		Second transplant		First transplant		Second transplant		First transplant	Second transplant			First transplant		Second transplant		First transplant	Second transplant			First transplant		Second transplant
	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks	4 weeks	12 weeks
Blood chemistry
13MW 302	28	32	29	31	36	35	35	31	3.1	3	3.1	3.2	2.3	2.3	2.1	2.3	175	168	174	178	90	92	92	97
13FW 191	21	28	28	29	41	42	45	43	3.3	3.2	3.1	3.4	2.3	2.9	2.8	2.7	252	169	167	191	98	86	95	95
13FW 283	26	31	26	30	34	43	36	40	3.1	3.1	3	3	2.2	2.4	2.6	2.7	160	134	155	137	90	82	89	87
13FW 956	21	26	23	23	33	35	34	42	3.5	3.4	3.3	3.6	2.7	2.7	2.6	2.9	173	159	157	170	84	87	84	80
13MW 1029	26	29	29	30	55	57	57	65	3.1	3	3.1	3.1	2.9	2.7	2.7	3	179	158	166	163	83	79	88	87
13FW 300	30	34	35	26	35	41	35	32	3.4	3.6	3.5	3.6	2.2	2.3	2.1	2.3	156	124	125	232	98	87	93	100
13FW 299	29	26	27	27	30	31	31	32	3.4	3.2	3.2	3.2	2.2	2.4	2.3	2.7	137	162	128	145	90	96	93	90
13FW 1031	18	24	24	18	37	39	37	41	3.1	3.3	3.5	3.3	2.3	2.5	2.6	2.4	237	185	261	232	98	97	93	97
13FW 926	29	28	41	22	50	56	54	157	3.6	3.6	3.7	3.4	2.8	3	2.8	3.1	172	176	173	256	86	79	85	92
13MW 1122	24	23	26	27	38	39	38	41	3.2	3.2	3.1	3.1	2.5	2.6	2.4	2.6	200	178	179	172	95	95	98	112

RBC erythrocyte count (red blood cells), WBC lymphocyte count (white blood cells), AST aspartate transminase, ALT alanine transminase

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ISSN: 1757-6512

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