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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression

Fig. 3

Neural differentiation of untransfected, topo IIβ-silenced, and -overexpressed hMSCs. a Morphology of untransfected, topo IIβ-silenced, and -overexpressed hMSCs induced to neural differentiation by the mN3 cytokine combination for 5 days. b Neural differentiation efficiencies and c neurite lengths of topo IIβ-silenced and -overexpressed cells at day (d)1, day 3, and day 5 were compared with untransfected cells. Both neural differentiation efficiency and neurite length were directly proportional to topo IIβ expression. The average total neurite length and neural differentiation efficiency per group for each day was determined from at least 100 images from random fields. Images ×10. Error bars represent the means ± standard deviation; *p < 0.01, **p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512