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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Co-stimulation of LPAR1 and S1PR1/3 increases the transplantation efficacy of human mesenchymal stem cells in drug-induced and alcoholic liver diseases

Fig. 1

LPA and/or S1P attenuates LPS/H2O2-induced stem cell death. a Changes in hADMSC viability after LPS/H2O2 intoxification in the presence or absence of LPA/S1P co-treatments (n = 4). b Distribution of hADMSC apoptotic fractions measured by flow cytometry. Upper right: late phase apoptotic ratio; Lower right: early phase apoptotic ratio. c Changes in hADMSC caspase-3/7 activity after LPS/H2O2 intoxification in the presence or absence of LPA/S1P co-treatments (n = 4). Data from each group are expressed as means ± SEM. Statistical comparison between groups was performed with the Kruskal–Wallis test followed by Dunn’s post-hoc test to detect differences in all groups. ***p < 0.001 versus control group; ##p < 0.01 versus LPS/H2O2 group; ###p < 0.001 versus LPS/H2O2 group; @@@p < 0.001 versus LPS/H2O2 + LPA or S1P group. Ctrl, control; LPA, lysophosphatidic acid; LPS, lipopolysaccharide; S1P, sphingosine-1-phosphate

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