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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Long noncoding RNA H19 upregulates vascular endothelial growth factor A to enhance mesenchymal stem cells survival and angiogenic capacity by inhibiting miR-199a-5p

Fig. 4

LncRNA-H19 enhanced angiogenic capacity of MSCs. a, b Results of tube formation assay in different groups under normoxia and H/SD conditions in vitro (magnification ×100). c Comparison of numbers of vascular branches among different groups under normoxia and H/SD conditions respectively. MSCs+H19, MSCs transfected with lncRNA-H19; MSCs+H19 NC, MSCs transfected with lncRNA-H19 scramble; MSCs+si-H19, MSCs transfected with lncRNA-H19 siRNA; MSCs+si-H19 NC, MSCs transfected with lncRNA-H19 siRNA scramble. **P < 0.01 vs MSCs, ##P < 0.01 vs MSCs+H19 NC, ††P < 0.01 vs MSCs+si-H19 NC. H/SD: hypoxia/serum deprivation, MSCs: mesenchymal stem cells, NC: scramble negative control

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Stem Cell Research & Therapy

ISSN: 1757-6512