Skip to main content
Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach

Fig. 2

Proteome profiling arrays (a) representing 55 proteins involved in angiogenesis and tissue regeneration were performed with the respective PCMO samples. Red rectangles represent upregulated proteins in supernatants of PCMO cell culture or cells by more than 25%. The nine most regulated proteins (b) in supernatants under hypoxia were: granulocyte-macrophage colony-stimulating factor (GM-CSF), heparin-binding EGF-like growth factor (HB-EGF), interleukin-8 (IL-8), monocyte chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1-alpha (MIP-1α), matrix metalloproteinase (MMP-9), pentraxin-related protein (PTX-3), serpin E1 and metallopeptidase inhibitor 1 (TIMP-1). The most regulated proteins (b) within PCMO under hypoxia were: angiogenin, coagulation factor III, interleukin-1 beta (IL-1β), interleukin-8 (IL-8), matrix metalloproteinase (MMP-9), platelet factor 4 (PF4), metallopeptidase inhibitor 1 (TIMP-1), thrombospondin-1 and urokinase-type plasminogen activator (uPA). The cell culture experiments showed a hypoxia-induced upregulation (c) by more than 25% of 10/55 (18%) proteins in supernatants and 3/55 (6%) proteins within the PCMO (*p < 0.05). PCMO programmable cells of monocytic origin

Back to article page