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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Acidic preconditioning of endothelial colony-forming cells (ECFC) promote vasculogenesis under proinflammatory and high glucose conditions in vitro and in vivo

Fig. 5

Acidic preconditioning improves endothelial colony-forming cell (EFCF) migration under stressful conditions. Nonpreconditioned or preconditioned ECFC (npECFC or pECFC, respectively) were treated with high glucose, tumor necrosis factor (TNF)α, or their combination, and the different angiogenic responses were measured. a The extent of cell migration into the scratched area was measured after 0, 6, and 18 h (n = 5). b Images show the kinetic of gap closure in npECFC or pECFC treated with both high glucose and TNFα. Original magnification, 40×. c Chemotaxis in response to SDF1 (20 ng/ml) was determined using transwell inserts. The number of migrated cells was counted after 6 h (n = 4). *p < 0.05 vs untreated npECFC; #p < 0.05 vs npECFC with the same treatment; &p < 0.05 vs TNFα or glucose alone

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Stem Cell Research & Therapy

ISSN: 1757-6512

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