Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents

Table 2 Spectral (UV and ESI-MS/MS) and chromatographic data (retention time, t_R) of phenols (1–14) detected in R. nigrum bud preparation

Peak	Compound	t_R (min)	M	[M − H]⁻	MS/MS base peak (m/z)	MS/MS ions (m/z)	λ_max (nm)
	Phenolic acids
1	Caffeoylquinic acid	17.7	354	353	179	191, 173, 135	257, 325
2	3-p-Coumaroylquinic acid	25.2	338	337	163	293, 203, 191,173	313
3	Caffeoylquinic acid	29.6	354	353	179	191, 173, 155, 135	257, 329
4	Caffeoylquinic acid	32.3	354	353	191	179, 173, 135	257, 329
5	4-p-Coumaroylquinic acid	41.6	338	337	173	293, 191, 173, 163, 155	313
7	5-p-Coumaroylquinic acid	45.8	338	337	191	293, 207, 173, 163	314
	Flavonol glycosides
6	Kaempferol di-hexoside	44.4	610	609	447	573, 489, 285, 179	270, 356
8	Myricetin 3-O-rutinoside	55.1	626	625	317	607, 479, 271, 243, 203, 179	270, 357
9	Myricetin 3-O-glucoside and/or myricetin 3-O-galactoside	55.9	480	479	317	461, 271, 179, 151	269, 358
10	Quercetin 3-O-rutinoside (rutin)	61.1	610	609	301	591, 447, 271, 243, 179	265, 356
11	Quercetin 3-O-glucoside (isoquercitrin) and/or quercetin 3-O-galactoside (hyperoside)	62.3	464	463	301	445, 273, 179	257, 356
12	Kaempferol 3-O-rutinoside	66.3	594	593	285	447, 257, 229, 179	270, 350
13	Kaempferol 3-O-glucoside (astragalin)	67.1	448	447	285	257, 229, 179	268, 349
14	Isorhamnetin glucoside and/or isorhamnetin galactoside	67.8	478	477	315	285, 271, 243, 229, 179	271, 356

ISSN: 1757-6512