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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1G93A and NSG animal models

Fig. 5

Effect of hES-AS transplantation on disease onset, motor activity and survival in hSOD1G93A rat ALS model. hES-AS (APCs differentiated for 7 days) injected intrathecally through lumbar puncture (L5–L6), in two doses of 3 × 106 cells each on days 50 and 70 after birth in hSOD1G93A rats. a Kaplan–Meir survival curves of rats treated with hES-AS (green) show prolongation of median survival compared to sham-injected group (vehicle, red). b Kaplan–Meir plot of disease onset (defined by 3% body weight loss) shows significant delay in hES-AS-treated ALS rats. c Body weight maintained significantly longer in hES-AS-treated ALS rats. d Neurological score. e Significant prolongation of motor performance on Rotarod in hES-AS-treated ALS rats. Same seen by grip strength measurement. c, d Values represent mean ± SEM

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