Table 1 hES-AS secrete a variety of factors with effects on neurons or with antiprotease activity

 Osteopontin (OPN)

53.1 ± 29

56.8 ± 5.5

 Dickkopf-3 (DKK-3)

43.1 ± 14.2

33.8 ± 1.6

 Thrombospondin (TSP-1)

22.7 ± 11.5

118.9 ± 36.8

 Secreted Frizzled Protein (sFRP3)

20.8 ± 10.9

41.2 ± 23.0

 Brevican proteoglycan

15.6 ± 4.9

12.6 ± 3.3

 Tripeptidyl peptidase (CLN2)

11.5 ± 4.2

20.1 ± 11.7

 Clusterin

9.5 ± 3.2

6.5 ± 0.5

 Midkine

8.4 ± 3.0

6.1 ± 3.5

 NSE

3.5 ± 1.8

0.9 ± 0.2

 MIF chemokine

1.8 ± 0.6

0.4 ± 0.1

 CXCL16

1.5 ± 0.8

2.1 ± 0.2

 Thrombospondin-2

0.85 ± 0.4

2.3 ± 0.4

 GRFα-1

0.45 ± 0.2

1.0 ± 0.6

 VEGF

0.05 ± 0.02

0.23 ± 0.09

 Fetuin A

1816.0 ± 677

1404.7 ±+ 129.4

 Tissue inhibitor of metalloprotease TIMP-2

16.6 ± 6.8

14.5 ± 0.8

 PAI-1 Serpine 1 protease inhibitor

7.2 ± 6.2

54.9 ± 5.9

 Tissue inhibitor of metalloprotease TIMP-1

7.0 ± 3.8

6.5 ± 0.8

 Serpin A4

4.3 ± 2.5

4.0 ± 0.4