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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells

Fig. 1

Impact of IL-1β and MLT on cartilage pellet development throughout chondrogenesis of human mesenchymal stem cells (hMSCs). hMSCs prompted into chondrogenesis in chondrogenic medium with vehicle, 10 ng/ml IL-1β and vehicle, or 10 ng/ml IL-1β and 50 nM MLT via high-density micromass culture system. Cartilage pellets cultured for 7 (a), 14 (c), and 21 (e) days and observed by stereoscopic microscope in representative samples. Scale bars: 0.5 mm. Perimeters of pellets cultured for 7 (b), 14 (d) and 21 (f) days of chondrogenesis , 12 pellets used for measurement in each group. g Growth tendency of pellets from day 7 to day 21 in different groups. aP < 0.05 versus control group; bP < 0.05 versus IL-1β group. IL-1β interleukin-1β, MLT melatonin

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