Fig. 4

The p-STAT3 signaling was involved in the regulation of iPSC-MSCs in the mouse model of steroid-resistant airway inflammation. The lung tissues were collected at 4 h after the challenge. a Western blot and statistical analysis of p-STAT1, p-STAT3 and p-STAT6 expressions in the lung tissues of neutrophilic airway inflammation model. b Western blot analysis showed that iPSC-MSCs but not DEX significantly decreased the level of p-STAT3 in the lung tissues. *P < 0.05 by the Mann-hitney U test. Abbreviations: DEX dexamethasone, iPSC-MSCs induced pluripotent stem cell-derived mesenchymal stem cells, ns not significant, nd not detected, PBS phosphate-buffered saline, OVA ovalbumin. n = 5 for PBS/PBS/PBS and OVA/OVA/PBS, n = 6 for OVA/OVA/DEX and OVA/OVA/MSC