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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Exosomes secreted by adipose-derived mesenchymal stem cells regulate type I collagen metabolism in fibroblasts from women with stress urinary incontinence

Fig. 5

adMSC-Exos regulate type I collagen metabolism in cultured vaginal fibroblasts from women with SUI. Fibroblasts were incubated with adMSC-Exos or SUI-Exos for 48 h. a The levels of Col1a1 in cultured vaginal fibroblasts from women with SUI were analyzed by qRT-PCR. The results are the mean ± s.d. (n = 3 for each group). **P < 0.01. b The expression of type I collagen was determined by a western blot assay. c The levels of TIMP-1, TIMP-3, MMP-1, and MMP-2 in fibroblasts from women with SUI were analyzed by qRT-PCR. The results are the mean ± s.d. (n = 3 for each group). adMSC-Exos exosomes secreted by adipose-derived mesenchymal stem cells, MMP-1 matrix metallopeptidase 1, MMP-3 matrix metallopeptidase 3, SUI stress urinary incontinence, TIMP-1 TIMP metallopeptidase inhibitor 1, TIMP-2 TIMP metallopeptidase inhibitor 2

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Stem Cell Research & Therapy

ISSN: 1757-6512