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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6

Fig. 4

EXO-depleted MSC-CM 25 wks injections does not reverse hyperoxia-induced pulmonary inflammation, altered morphology, PH and RVH in the BPD mouse brain. a-c Histograms showing BALF total cell count (a), BALF absolute neutrophil count (b), total BALF protein (c) in RA, BPD, DMEM:F12-injected, MSC-CM 25 wks and EXO-depleted MSC-CM 25 wks-injected BPD mice at PN14. d-f Histograms showing the mean chord length (d), septal thickness (e), alveolar area (f) in lungs of RA, BPD, DMEM:F12-injected, MSC-CM 25 wks and EXO-depleted MSC-CM 25 wks-injected BPD mice. g-h Graph demonstrating PAAT/PAET ratio (g), RV to LV ratio (h), reflecting RV hypertrophy, in the five experimental groups at PN14. MSC-CM 25 wks data set used earlier in this manuscript was used for comparison with the EXO- depleted MSC-CM 25 wks group. All values are expressed as mean ± SEM; five experiments, N = 3–9 mice per group; one-way ANOVA with Tukey’s post hoc correction; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. BPD bronchopulmonary dysplasia, CM conditioned medium, EXO exosomes, LV left ventricular, MSC mesenchymal stem cell, PAAT pulmonary artery acceleration time, PAET pulmonary artery ejection time, PBS phosphate-buffered saline, RA room air, RV right ventricular

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