Fig. 6

TSG-6 treatment corrects PH and RVH and attenuates hypomyelination and GFAP decrease in BPD mouse brain. a Echocardiography shows reversal of cardiac dysfunction on TSG-6 treatment in the BPD mouse model. The white line in the echocardiogram depicts PAAT values for specific group. b Graph demonstrating PAAT values from the four experimental groups at PN14. c Graph depicting PAAT/PAET ratio from the four experimental groups at PN14. d Histogram showing the RV to LV ratio in the four experimental groups. e Fulton’s index, [RV/(LV + IVS)], reflecting RV hypertrophy, in the four experimental groups at PN14. All values are expressed as mean ± SEM; four experiments, N = 3–8 mice per group; one-way ANOVA with Tukey’s post hoc correction; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. BALF bronchoalveolar lavage fluid, BPD bronchopulmonary dysplasia, CM conditioned medium, IVS interventricular septa, LV left ventricular, PBS phosphate-buffered saline, RA room air, RV right ventricular, TSG-6 tumor necrosis factor alpha-stimulated gene-6