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Table 1 Clinical characteristics and outcome of patients

From: Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial

Patient

Age (years)

Symptoms

Etiology

Prior repair attempts

Hysteroscopy (IUA score) pre-/3-month post-UC-MSC therapy

Pregnancy outcome

P1

34

Infertility (5 years), Hypomenorrhea

3 D&C

2 HSP

10/4

Spontaneous pregnancy 21 months post treatment and cesarean section at 37+ 6 weeks, boy, 3300 g

P2

34

Infertility (5 years), Hypomenorrhea

4 D&C

2 HSP

10/8

 

P3

39

Infertility (7 years), Hypomenorrhea

7 D&C

1 HSP

6/0

IVF-ET and implantation failure

P4

33

Infertility (2 years), Hypomenorrhea

6 D&C

2 HSP

10/6

Spontaneous pregnancy 16 months post treatment and cesarean section at 38+ 1 weeks, girl, 3200 g

P5

33

Infertility (2 years), Hypomenorrhea

1 D&C

1 HSP

6/4

Spontaneous pregnancy 11 months post treatment and cesarean section at 29+ 5 weeks, boy, 1690 g

P6

33

Infertility (14 years), Hypomenorrhea

Unknown

2 HSP

10/10

 

P7

42

Infertility (2 years), Hypomenorrhea

1 D&C

2 HSP

10/7

 

P8

37

Infertility (2 years), Hypomenorrhea

7 D&C

4 HSP

10/4

 

P9

27

Infertility (5 years), Hypomenorrhea

3 D&C

5 HSP

10/10

 

P10

31

Infertility (2 years), Hypomenorrhea

spontaneous abortion

2 HSP

10/5

IVF-ET 16 months post treatment and cesarean section at 37+ 5 weeks, girl, 3400 g

P11

34

Infertility (8 years), Hypomenorrhea

Unknown

4 HSP

10/10

 

P12

30

Infertility (4 years), Hypomenorrhea

2 D&C

2 HSP

10/8

 

P13

41

Infertility (2 years), Hypomenorrhea

2 D&C

6 HSP

8/4

 

P14

40

Infertility (8 years), Hypomenorrhea

3 D&C

1 HSP

10/6

 

P15

34

Infertility (2 years), Amenorrhea

4 D&C

1 HSP

10/0

Spontaneous pregnancy 20 months post treatment and delivered at 40+ 4 weeks, boy, 3450 g

P16

34

Infertility (3 years), Hypomenorrhea

spontaneous abortion

1 HSP

10/7

IVF-ET and implantation failure

P17

33

Infertility (5 years), Hypomenorrhea

4 D&C

6 HSP

7/3

IVF-ET 5 months post treatment and cesarean section at 37+ 5 weeks, boy, 3600 g

P18

32

Infertility (6 years), Hypomenorrhea

3 D&C

1 HSP

7/0

IVF-ET 15 months post treatment and cesarean section at 27+ 3 weeks, boy, 1100 g

P19

37

Infertility (5 years), Hypomenorrhea

10 D&C

2 HSP

10/8

Spontaneous pregnancy 24 months post treatment and ongoing third trimester pregnancy

P20

40

Infertility (3 years), Hypomenorrhea

2 D&C

1 HSP

8/0

Spontaneous pregnancy 10 months post treatment and cesarean section at 37+ 4 weeks, girl, 3930 g

P21

33

Infertility (2 years), Hypomenorrhea

4 D&C

1 HSP

10/4

 

P22

40

Infertility (3 years), Normal menstruation

7 D&C

2 HSP

10/8

 

P23

35

Infertility (5 years), Hypomenorrhea

5 D&C

1 HSP

10/10

Spontaneous pregnancy 26 months post treatment and abortion at 7th week

P24

30

Infertility (3 years), Hypomenorrhea

3 D&C

4 HSP

10/6

 

P25

36

Infertility (6 years), Normal menstruation

2 D&C

1 HSP

6/6

 

P26

34

Infertility (5 years), Hypomenorrhea

1 D&C

4 HSP

10/refused to follow-up

 
  1. D&C dilatation and curettage, HSP hysteroscopic adhesiolysis, IVF-ET in vitro fertilization-embryo transfer
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Stem Cell Research & Therapy

ISSN: 1757-6512