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Fig. 11 | Stem Cell Research & Therapy

Fig. 11

From: Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor

Fig. 11

Model for the regulation of ML141-induced hepatocyte differentiation. In hADSCs, ML141 induced the hepatocyte differentiation by a mechanism involving the Wnt5a/PI3K/miR-122 signaling pathway, and regulated positively the hepatic specific genes and function, importantly the exosome release. ALB albumin, HNF hepatocyte nuclear factor, NSC NSC5476, PI3K phosphatidylinositol-3 kinase, WRT Wortmannin

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Stem Cell Research & Therapy

ISSN: 1757-6512