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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor

Fig. 5

Extinction of alpha fetoprotein (AFP), Vimentin, and Ki67 from hepatocyte-like cells derived from aged ADSCs treated with ML141. Cells derived from young and aged groups were differentiated and treated with or without ML141 as indicated in Fig. 4 and evaluated for AFP (fetal hepatoblast marker), Vimentin (EMT marker), and Ki67 (proliferation marker) by immunohistochemistry (IHC) as described in the Methods. Cells were examined microscopically and phase-contrast images were captured. Cultures of primary human (h) fetal and adult hepatocytes were assessed as positive controls and negative controls, respectively

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