Fig. 8

Effects of the clustered fusion protein-mediated activation of Eph/Ephrin signaling on BM-MSC morphology. a–c The formation of MSC aggregates in treated cultures begins with the progressive coalescence of nonadhered cells (a) that initially form small cellular groups (b) to finally group in cell masses (c). In other areas of cultures, treatments generate empty areas (d) due to retraction of cell processes (e, arrows). Sometimes, cell masses form “bridges” to connect each to other (f, arrow). Scale bars = 200 μm (a–d) and 100 μm (e)