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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death

Fig. 9

MSC cytoskeleton changes after treatment with clustered Eph/Ephrin-Fc fusion proteins. a Control MSC spread well on the plate showing a wide actin (red) and vimentin (green) network throughout the cell cytoplasm. In contrast, clustered Eph/Ephrin-Fc treated cells that form cell masses with numerous nuclei (blue) (b, c, arrows) exhibit a less expanded cytoskeletal network. Remarkably, isolated treated MSC (d) show profound morphological alterations with small clusters of vimentin in the tips of cell processes or attached areas to plate in rounded cells (arrows). Scale bars = 50 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512