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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Neural stem cell therapy for subacute and chronic ischemic stroke

Fig. 1

Schematic diagram of NSC generation via multiple methods. NSCs can be extracted directly from neurogenic niches, including the subgranular zone (SGZ) of the hippocampal dentate gyrus and subventricular zone (SVZ) of the lateral ventricles, from adult or fetal neural tissue and expanded in vitro. NSCs can be reprogrammed from patient-derived induced pluripotent stem cells by using combinations of specific transcription factors, small molecules, microRNAs, plasmids, and other morphogens. In addition, NSCs can be generated from blastocyst-derived embryonic stem cells by using specific combinations of differentiation factors, such as morphogens and extracellular matrix (ECM) proteins. Abbreviation: NSC neural stem cell

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