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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Pericellular collagen I coating for enhanced homing and chondrogenic differentiation of mesenchymal stem cells in direct intra-articular injection

Fig. 6

Macroscopic observation and histological scoring. a. Macroscopic observation of postoperative cartilage defects. b Macroscopic observation of cartilage defects after cell transplantation at 6 and 12 weeks (n = 4 in each group). c. ICRS score of blank, MSCs, and MSCs-PCC groups after injection at 12 weeks. d Safranin O-Fast Green staining (scale bars of 4× and 10× images, 100 μm and 40 μm respectively; n = 4 in each group). e Modified Wakitani score of MSCs and MSCs-PCC groups after injection at 12 weeks (P = 0.0202, n = 4 in each group). f Immunohistochemical expression of col. I, col. II, and col. X in full-thickness chondral defects in trochlear groove at 12 weeks after injection of MSCs and MSCs-PCC (scale bar, 100 μm; n = 4 in each group)

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Stem Cell Research & Therapy

ISSN: 1757-6512