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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration

Fig. 6

Molecular dynamics simulation and refinement of both deer and human TMSB10 structure. a Sequence alignment of TMSB10 (deer and human) and template (bovine). b 3D structure of both deer and human TMSB10. In the docked structure, the α-helix (red) and the β-turn (green) are presented. The loop is represented by the color white. c The Cα root mean square fluctuation (RMSF) of each residue for both deer (black) and human (red) TMSB10. d, e The Ramachandran plot of deer TMSB10 (d) and human TMSB10 (e) using the Procheck program. The green dots represent residues of TMSB10. The dots surrounded by a curve (cyan) indicate that the residues are in the most favored region. The dots outside the cyan region but in the pink region equate to residues in an additional allowed region (Lys3, Glu37, Gln39, Ala40 for deer TMSB10, and Asp2, Met6 for human TMSB10). The red dots outside the pink region mean the residue is in the disallowed region (Asp2 and Met6 for deer TMSB10). f The root mean square deviation (RMSD) of both deer (black) and human (red) TMSB10 during 100 ns MD simulation. g, h The evaluation of deer (g) and human (h) TMSB10 final structure by Profile-3D program. All the scores of residues are above zero; this means the residues are in credible positions

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