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Table 2 Failed detection of HBV in culture medium and lysate supernatant of MSCs derived from HBV-infected donors

From: Reflection and observation: cell-based screening failing to detect HBV in HUMSCs derived from HBV-infected mothers underscores the importance of more stringent donor eligibility to reduce risk of transmission of infectious diseases for stem cell-based medical products

Donor   HBsAg Anti-HBs HBeAg Anti-HBeAg Anti-HBc HBV DNA
No. 1 1st passage medium
3rd passage medium
3rd passage cell lysate
No. 2 1st passage medium
3rd passage medium
3rd passage cell lysate
No. 3 1st passage medium
3rd passage medium
3rd passage cell lysate
  1. HBV hepatitis B virus, MSC mesenchymal stem cell, HBsAg hepatitis B surface antigen, Anti-HBs antibody to HBsAg, HBeAg hepatitis B e-antigen, Anti-HBe antibody to HBeAg, Anti-HBc antibody to hepatitis B core antigen