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Table 2 Failed detection of HBV in culture medium and lysate supernatant of MSCs derived from HBV-infected donors

From: Reflection and observation: cell-based screening failing to detect HBV in HUMSCs derived from HBV-infected mothers underscores the importance of more stringent donor eligibility to reduce risk of transmission of infectious diseases for stem cell-based medical products

Donor

 

HBsAg

Anti-HBs

HBeAg

Anti-HBeAg

Anti-HBc

HBV DNA

No. 1

1st passage medium

–

–

–

–

–

–

3rd passage medium

–

–

–

–

–

–

3rd passage cell lysate

–

–

–

–

–

–

No. 2

1st passage medium

–

–

–

–

–

–

3rd passage medium

–

–

–

–

–

–

3rd passage cell lysate

–

–

–

–

–

–

No. 3

1st passage medium

–

–

–

–

–

–

3rd passage medium

–

–

–

–

–

–

3rd passage cell lysate

–

–

–

–

–

–

  1. HBV hepatitis B virus, MSC mesenchymal stem cell, HBsAg hepatitis B surface antigen, Anti-HBs antibody to HBsAg, HBeAg hepatitis B e-antigen, Anti-HBe antibody to HBeAg, Anti-HBc antibody to hepatitis B core antigen