Fig. 3

Effect of exosome treatment on wound healing in vivo after 7 days. a A representative image of a Masson’s trichrome stained wound displaying the length of a control wound. Complete wound images were scanned under 2.5× magnification. b A representative exosome-treated wound displaying the healing progress at the end of 7 days. c Representative 40× image from the center of the granulation tissue of a control wound displaying cells and granulation within the wound center. d Representative 40× image from the center of the granulation tissue of exosome-treated wound, displaying cells and granulation within the wound center. e Quantification of the measurement of the granulation length from blue to blue across the wound. f Quantification of the cell number within the wound bed from 40× images. g Quantification of blue granulation intensity from within the wound center, determined by a score out of 10 by three blinded individuals, 1 being lowest and 10 being highest. N = 4 control mice, N = 4 exosome-treated mice. Arrow heads point to the start and end of granulation tissue within the wound bed. * p < 0.05