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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Prevascularization promotes endogenous cell-mediated angiogenesis by upregulating the expression of fibrinogen and connective tissue growth factor in tissue-engineered bone grafts

Fig. 4

Prevascularization promotes synthesis of collagen type I/III. (A) At 1 week after operation, sirius red staining in tissue section. White arrow, implanted blood vessel; scale bars = 200 μm. (B) Sirius red staining of TEBG sections (a–c) and prevascularized TEBG sections (a′–c′) at 4 weeks; scale bars =100 μm. White arrow, implanted blood vessel; red arrow, region near callus. (C) Relative deposition area of type I and type III collagen, relative IOD of type III collagen, and ratio of type III collagen to the total area of type I and type III collagen, n = 4. Data presented as mean ± s.e.m. **P < 0.01, *** P < 0.001 determined by Student t tests. COL collagen, TEBG tissue-engineered bone graft

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Stem Cell Research & Therapy

ISSN: 1757-6512