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Table 3 Studies reporting use of uncommon stem cell types

From: Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research

Author

Year

Species

Study design

Type of cell

Administration route

Results

Badillo et al. [58]

2007

Mouse

Three groups:

- MSC

- CD45+

- Control

Allogeneic, murine, embryonic, fetal liver MSC

Intradermal

MSC group showed smaller epithelial gap than CD45+ group (P < 0.004)

MSC group showed increased granulation tissue area compared to control group (P < 0.05)

Barcelos et al. [29]

2009

Mouse

Three groups:

- CD133+ cells

- CD133– cells

- Control

Human fetal aorta-derived CD133+ progenitor cells

Collagen hydrogel

CD133+ group showed accelerated wound healing compared to control group (P < 0.05)

Lee et al. [53]

2011

Rat

Four groups:

- Nondiabetic control rats

- Diabetic rats treated with saline

- Diabetic rats treated with saline and insulin

- Diabetic rats treated with ESC and insulin

Mouse embryonic stem cells

Cell suspension drops

ESC and insulin-treated group wound healing accelerated compared to saline and insulin-treated group (P < 0.05)

Kim et al. [60]

2012

Mouse

Four groups:

- Amniotic MSC

- ADSC

- Human dermal fibroblasts

- Control

Human ADSC and human amniotic mesenchymal stem cells

Intradermal

Amniotic MSC group showed accelerated wound healing compared with ADSC, dermal fibroblasts or control groups (P < 0.01)

Kong et al. [41]

2013

Rat

Two groups:

- Human placenta MSC

- Control

Human placenta MSC

Intradermal

Placenta MSC group showed better wound closure compared to control group (P < 0.01)

Zheng et al. [18]

2017

Mouse

Three groups:

- Living micronized amniotic membrane

- Decellularized micronized amniotic membrane

- Control

Human amniotic epithelial cells (HAECs)

Micronized amniotic membrane

Living membrane group had greater wound healing rate than decellularized membrane or control groups (P < 0.001)

Lv et al. [16]

2017

Rat

Three groups:

- Exfoliated deciduous teeth stem cells

- BM-MSC

- Control

Human BM-MSC and human exfoliated deciduous teeth (SHED)

Local injection

SHED group showed accelerated wound healing compared to both BM-MSC and control groups (P < 0.05)

  1. ADSC adipose tissue-derived mesenchymal stem cells, BM-MSC bone marrow-derived mesenchymal stem cells, ESC embryonic stem cells, MSC mesenchymal stem cells