From: Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research
Author | Year | Species | Study design | Type of cell | Administration route | Results |
---|---|---|---|---|---|---|
Badillo et al. [58] | 2007 | Mouse | Three groups: - MSC - CD45+ - Control | Allogeneic, murine, embryonic, fetal liver MSC | Intradermal | MSC group showed smaller epithelial gap than CD45+ group (P < 0.004) MSC group showed increased granulation tissue area compared to control group (P < 0.05) |
Barcelos et al. [29] | 2009 | Mouse | Three groups: - CD133+ cells - CD133– cells - Control | Human fetal aorta-derived CD133+ progenitor cells | Collagen hydrogel | CD133+ group showed accelerated wound healing compared to control group (P < 0.05) |
Lee et al. [53] | 2011 | Rat | Four groups: - Nondiabetic control rats - Diabetic rats treated with saline - Diabetic rats treated with saline and insulin - Diabetic rats treated with ESC and insulin | Mouse embryonic stem cells | Cell suspension drops | ESC and insulin-treated group wound healing accelerated compared to saline and insulin-treated group (P < 0.05) |
Kim et al. [60] | 2012 | Mouse | Four groups: - Amniotic MSC - ADSC - Human dermal fibroblasts - Control | Human ADSC and human amniotic mesenchymal stem cells | Intradermal | Amniotic MSC group showed accelerated wound healing compared with ADSC, dermal fibroblasts or control groups (P < 0.01) |
Kong et al. [41] | 2013 | Rat | Two groups: - Human placenta MSC - Control | Human placenta MSC | Intradermal | Placenta MSC group showed better wound closure compared to control group (P < 0.01) |
Zheng et al. [18] | 2017 | Mouse | Three groups: - Living micronized amniotic membrane - Decellularized micronized amniotic membrane - Control | Human amniotic epithelial cells (HAECs) | Micronized amniotic membrane | Living membrane group had greater wound healing rate than decellularized membrane or control groups (P < 0.001) |
Lv et al. [16] | 2017 | Rat | Three groups: - Exfoliated deciduous teeth stem cells - BM-MSC - Control | Human BM-MSC and human exfoliated deciduous teeth (SHED) | Local injection | SHED group showed accelerated wound healing compared to both BM-MSC and control groups (P < 0.05) |