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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

Fig. 1

Therapeutic effects of ASC-exosomes on AD-like lesions in NC/Nga mice. a The study protocol. b Representative skin manifestations in NC/Nga mice at days 0 and 28, H&E staining results, toluidine blue staining results, and immunohistochemical staining of CD86+ or CD206+ cells of ear skin samples from AD mice. Enlarged images of toluidine blue staining for mast cells and immunostaining for CD86 and CD206 are shown in Additional file 1: Figures S4–S6, respectively. Indicated amounts of ASC-exosomes (micrograms/head) were administered either by IV or SC thrice a week for 4 weeks. c Relative percentage improvement of clinical skin severity scores compared to vehicle group. Percentage improvement was calculated as described in Additional file 1: Materials and methods. d Improvement of ear thickness as measured in H&E-stained tissue sections in b. e The number of mast cells in the skin lesions determined in toluidine blue-stained tissue sections in b. Quantitative analysis of CD86+ (f) and CD206+ (g) cells as determined in tissue sections in b. Results are presented as mean ± standard error of the mean; n = 10 for each group. *P < 0.05, **P < 0.01, and ***P < 0.001 vs vehicle control group. IV intravenous administration, SC subcutaneous administration, Pred prednisolone

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