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Table 2 Top 10 genes for degree in PPI network for DEGs between HLCs and PHHs

From: Analysis of differentially expressed genes among human hair follicle–derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes

Gene Degree Top P-value KEGG pathway Top P-value GOTERM_BP_FAT Fold change
Upregulated DEGs
TOP2A 260 None GO:0000278: mitotic cell cycle 218.0750636
CDK1 235 hsa04110: cell cycle GO:0000278: mitotic cell cycle 11.94033162
CCNB1 198 hsa04110: cell cycle GO:0000278: mitotic cell cycle 30.20813056
MYC 196 hsa04110: cell cycle GO:0007049: cell cycle 6.04915656
PCNA 193 hsa04110: cell cycle GO:0000278: mitotic cell cycle 5.543822244
Downregulated DEGs
ALB 250 None GO:0010876: lipid localization 9.20E-05
ACACB 151 hsa01100: metabolic pathways GO:0006082: organic acid metabolic process 0.009806799
DECR1 138 None GO:0006082: organic acid metabolic process 0.159393422
DPYD 128 hsa01100: metabolic pathways GO:0006082: organic acid metabolic process 0.015090098
EHHADH 115 hsa01100: metabolic pathways GO:0006082: organic acid metabolic process 0.020681003
  1. DEG differentially expressed gene, GO Gene Ontology, HLC hepatocyte-like cell, PHH primary human hepatocyte, KEGG Kyoto Encyclopedia of Genes and Genomes, PPI protein–protein interaction