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Table 2 Top 10 genes for degree in PPI network for DEGs between HLCs and PHHs

From: Analysis of differentially expressed genes among human hair follicle–derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes

Gene

Degree

Top P-value KEGG pathway

Top P-value GOTERM_BP_FAT

Fold change

Upregulated DEGs

TOP2A

260

None

GO:0000278: mitotic cell cycle

218.0750636

CDK1

235

hsa04110: cell cycle

GO:0000278: mitotic cell cycle

11.94033162

CCNB1

198

hsa04110: cell cycle

GO:0000278: mitotic cell cycle

30.20813056

MYC

196

hsa04110: cell cycle

GO:0007049: cell cycle

6.04915656

PCNA

193

hsa04110: cell cycle

GO:0000278: mitotic cell cycle

5.543822244

Downregulated DEGs

ALB

250

None

GO:0010876: lipid localization

9.20E-05

ACACB

151

hsa01100: metabolic pathways

GO:0006082: organic acid metabolic process

0.009806799

DECR1

138

None

GO:0006082: organic acid metabolic process

0.159393422

DPYD

128

hsa01100: metabolic pathways

GO:0006082: organic acid metabolic process

0.015090098

EHHADH

115

hsa01100: metabolic pathways

GO:0006082: organic acid metabolic process

0.020681003

  1. DEG differentially expressed gene, GO Gene Ontology, HLC hepatocyte-like cell, PHH primary human hepatocyte, KEGG Kyoto Encyclopedia of Genes and Genomes, PPI protein–protein interaction