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Table 3 Top 10 genes for MCODE score in PPI network for upregulated DEGs between HLCs and PHHs

From: Analysis of differentially expressed genes among human hair follicle–derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes

Gene MCODE score Top P-value KEGG pathway Top P-value GOTERM_BP_FAT Fold change
AURKA 57.86384977 hsa04114: oocyte meiosis GO:0000278: mitotic cell cycle 3.351277145
AURKB 57.86384977 None GO:0000278: mitotic cell cycle 3.114371397
CDCA8 57.86384977 None GO:0000278: mitotic cell cycle 4.028863704
MCM4 57.74647887 hsa04110: cell cycle GO:0000278: mitotic cell cycle 10.1500716
ANLN 57.67123288 None GO:0000278: mitotic cell cycle 201.1978391
HMMR 57.67123288 hsa04512: ECM-receptor interaction GO:0000278: mitotic cell cycle 9.742803711
KIF2C 57.64840183 None GO:0000278: mitotic cell cycle 7.390090337
HJURP 57.28985507 None GO:0007049: cell cycle 3.334170774
KIF4A 57.28985507 None GO:0000278: mitotic cell cycle 8.522401381
RAD51 57.24546464 hsa05200: pathways in cancer GO:0007049: cell cycle 3.486689757
  1. DEG differentially expressed gene, ECM extracellular matrix, GO Gene Ontology, HLC hepatocyte-like cell, PHH primary human hepatocyte, KEGG Kyoto Encyclopedia of Genes and Genomes, PPI protein–protein interaction
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Stem Cell Research & Therapy

ISSN: 1757-6512