Fig. 6

Effects of ICN1-induced arterial specification of ECs on vascular repair in ischemic limbs. a iICN1-ECs treated with or without Dox for 3 days and then injected intramuscularly to injury sites of nude mice with hindlimb ischemia. As negative control, HBSS buffer injected into ischemic limb. Representative photographs and laser Doppler perfusion imaging (LDPI) of mice on day 0 and day 21 shown. b. Time-course quantitative analysis of blood flow using LDPI of mice. Data represent mean ± SD (n = 4). *p < 0.05 Dox– vs control; #p < 0.05, ###p < 0.001 Dox+ vs control; $p < 0.05, Dox+ vs Dox–. Dox doxycycline