Fig. 5
From: The march of pluripotent stem cells in cardiovascular regenerative medicine
The Cre-Lox excision system. The DNA sequences for the OSKM factors are flanked by LoxP sites and delivered virally to the target cells of interest. The Cre-recombinase is delivered in parallel in a similar manner. When expressed, the Cre-recombinase excises the sequences by recombination of the two flanking LoxP sites. This excision will nevertheless leave a residual LoxP site at the site of the original insertion