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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells

Fig. 1

JMJD6 knockdown elevates migration in ADSCs. a Histone demethylase gene expression profiling in ADSCs. The mRNA expression of 27 histone demethylases was measured using RT-PCR. b qRT-PCR analysis of histone demethylase gene expression. ADSCs were transfected with targeted siRNAs, fold changes are relative to that of ADSCs treated with the scrambled (Scr) siRNA. c and d Cell migration assay showing the relationship between profiled histone demethylases and cell migration. ADSCs were treated with different siRNAs and were allowed to migrate to α-MEM with 20% FBS. After 18 h, CFSE prestained cells were fixed and counted. Scale bar = 200 μm, magnification = ×100, n = 3/group, Error bars represent the SD. **p < 0.01; *p < 0.05 versus the controls. ADSCs adipose-derived mesenchymal stem cells, JMJD6 Jumonji C domain-containing protein 6

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