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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells

Fig. 7

JMJD6 as an epigenetic regulator modulate PDE1C-cAMP/cGMP-dependent proliferation and migration in ADSCs. JMJD6 is the main H4R3me2a demethylase in ADSCs that epigenetically modulate PDE1C expression by binding upstream of PDE1C promoter and demethylating H4R3me2a at the PDE1C promoter. PDE1C can hydrolyze both cAMP and cGMP into 5’ AMP and 5’ GMP, which are intracellular secondary messengers, whose related functions are regulated by PDE1C. ADSCs adipose-derived mesenchymal stem cells, cAMP cyclic hydrolysis both cyclic adenosine monophosphate, cGMP cyclic guanosine monophosphate, H4R3me2a histone dimethyl asymmetric H4R3, PDE1C phosphodiesterase 1C, JMJD6 Jumonji C domain-containing protein 6

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