New insights into the genic and metabolic characteristics of induced pluripotent stem cells from polycystic ovary syndrome women

Table 2 The top 10 significantly downregulated genes in polycystic ovary syndrome patient-derived induced pluripotent stem cells

Gene name	Gene number	Gene Ontology molecular function term	Fold-change
FN1	NM_002026	Cell adhesion, protein binding, inflammatory response	0.001
NTS	NM_006183	Neuropeptide hormone activity, signal transduction	0.002
CER1	NM_005454	Cytokine activity, morphogen activity, BMP binding	0.002
SPP1	NM_000582	Cytokine activity, ossification, transforming growth factor (TGF)-β signaling	0.003
SLC7A3	NM_001048164	Amino acid and ion transport, transmembrane transport	0.003
SLC2A3	NM_006931	Glucose transmembrane transporter activity	0.004
ZFP42	NM_174900	Sequence-specific DNA binding transcription activity,	0.004
HAS2	NM_005328	Hyaluronan synthase activity, kidney development	0.005
PTPRZ1	NM_001206838	Protein dephosphorylation, axonogenesis	0.005
CDH1	NM_004360	Calcium ion binding, protein phosphatase binding	0.006

ISSN: 1757-6512