Table 3 The top 10 significantly upregulated genes in polycystic ovary syndrome patient-derived induced pluripotent stem cells
Gene name | Gene number | Gene Ontology molecular function term | Fold-change |
|---|---|---|---|
IFI16 | NM_001206567 | Transcription, cell proliferation, hemopoiesis | 1484 |
CAPN6 | NM_014289 | Calcium-dependent cysteine-type endopeptidase | 221.7 |
LAMA4 | NM_001105206 | Extracellular matrix structural constituent | 151.6 |
IL18 | NM_001562 | MAPK cascade, inflammatory and immune response | 96.9 |
FOLH1B | NM_153696 | Metallopeptidase and dipeptidase activity, proteolysis | 80.2 |
FOLH1 | NM_004476 | Folic acid-containing compound metabolic process | 78.2 |
TBX5 | NM_080718 | Transcription factor activity, heart development | 76.4 |
FBP1 | NM_000507 | AMP binding, fructose and glucose metabolic process | 69.2 |
AGL | NM_000028 | Glycogen debranching enzyme, glucose metabolism | 42.7 |
KIAA1324 | NM_020775 | Macroautophagy, regulation of apoptosis, trans-Golgi | 29.6 |