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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD

Fig. 8

hADSC-Exos repress apoptosis genes through SMAD pathway. a Western blot analysis of protein expression levels of Fas, FasL, Caspase-8, and Caspase-3 after hADSC-Exos coculture with hGCs. b Western blot analysis of protein expression levels of Fas, FasL, Caspase-8, and Caspase-3 after SMAD2, SMAD3, and SMAD5 knockdown in normal hGCs. c Proposed model for exosomes derived from hADSCs improved ovaries of POI mice through regulating SMAD pathway. Error bars indicate SD. **p < 0.01, ***p < 0.001 (compared with normal group). GAPDH glyceraldehyde 3-phosphate dehydrogenase, POI premature ovarian insufficiency, PBS phosphate buffered saline, EXO exosome, siRNA small interfering RNA, hADSC human adipose mesenchymal stem cells

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