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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease

Fig. 6

Effect of human bmMSCs, ucMSCs or kPSCs on claudin 1 and fibronectin expression in activated PECs. a, b Representative images and quantification of claudin 1 expression in PECs exposed to medium alone and angiotensin II (Ang II) (a) or albumin (alb) (b) and co-cultured with bmMSCs, ucMSCs or kPSCs. PEC nuclei stained with DAPI (blue). Data expressed as MFI/cell. **p < 0.01 and ***p < 0.001 vs PECs; °°p < 0.01 and °°°p < 0.001 vs PECs + Ang II or alb; #p < 0.05 vs PECs + alb + kPSCs; ###p < 0.001 vs PECs + Ang II + kPSCs. c, d Representative images and quantification of fibronectin (red) production by PECs exposed to medium alone and Ang II (c) or alb (d) and co-cultured with bmMSCs, ucMSCs or kPSCs for 24 h. PEC nuclei stained with DAPI (blue). Data expressed as MFI/cell. ***p < 0.001 vs PECs; °p < 0.05 vs PECs + alb; °°°p < 0.001 vs PECs + Ang II or alb. Data are mean ± SE. Scale bar 20 μm. bmMSC bone marrow-derived mesenchymal stromal cell, DAPI 4′,6-diamidino-2-phenylindole, kPSC kidney perivascular stromal cell, MFI mean fluorescence intensity, PEC parietal epithelial cell, ucMSC umbilical cord-derived mesenchymal stromal cell

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