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Table 1 Time course of urinary protein excretion in control and ADR rats receiving saline, bmMSCs, ucMSCs, kPSCs or CM-ucMSCs

From: Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease

 

Proteinuria (mg/day)

 

0 days

7 days

14 days

21 days

28 days

Control

6 ± 1.1

10 ± 1.3

12 ± 1.2

13 ± 1.3

13 ± 1.7

ADR + saline

7 ± 0.6

71 ± 7*

344 ± 29*

528 ± 26*

501 ± 53*

ADR + bmMSCs

7 ± 0.7

59 ± 12*

270 ± 19*

411 ± 17*

526 ± 36*

ADR + ucMSCs

7 ± 0.6

71 ± 11*

345 ± 16*

476 ± 15*

512 ± 43*

ADR + kPSCs

7 ± 0.4

63 ± 11*

355 ± 28*

471 ± 52*

486 ± 38*

ADR + CM-ucMSCs

8 ± 0.6

73 ± 13*

366 ± 40*

527 ± 37*

454 ± 48*

  1. Data presented as mean ± standard error
  2. ADR adriamycin, bmMSC bone marrow mesenchymal stromal cell, ucMSC umbilical cord mesenchymal stromal cell, kPSC kidney perivascular stromal cell, CM-ucMSC conditioned medium obtained from umbilical cord mesenchymal stromal cell
  3. *p < 0.001 vs control at the corresponding time. Analysis of variance corrected with Tukey coefficient