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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

Fig. 1

Identification of EPCs from human umbilical cord blood and protein expression during replicative aging. a EPCs (passage (P)1) after 2 weeks (100×). b Cells were characterized by immunofluorescence detection of CD31, CD34, von Willebrand factor (VWF), vascular endothelial growth factor receptor 2 (VEGFR2), and CD133. c Morphology of aging EPCs (100×). d, e Senescence-associated beta-galactosidase (SA-β-gal) staining at P3, P12, and P21. fh Protein levels of poly (ADP-ribose) polymerase 1 (PARP1), poly ADP-ribose (PAR), sirtuin 1 (SIRT1), acetylated (ac)-p53, p53, and p21 during replicative senescence. *P < 0.05, **P < 0.01, ***P < 0.001, versus the control

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