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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

Fig. 7

Schematic illustration of poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) crosstalk. In EPCs, H2O2 results in DNA damage, PARP1 activation, and consequent nicotinamide adenine dinucleotide (NAD+) consumption. PJ34 preserves intracellular NAD+ levels and increases SIRT1 deacetylation. ROS reactive oxygen species

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